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| 336 BC |
| | At a summer feast to celebrate the wedding of his daughter, Philip of Macedon is murdered by one of his courtiers | |
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| 336 BC |
| | The League of Corinth elects Alexander to take his father's place as leader of the campaign against Persia | |
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| 335 BC |
| | Before departing for the east, Alexander destroys Thebes and enslaves the Thebans for rebelling against the League of Corinth | |
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| 334 BC |
| | The 21-year-old Alexander the Great marches east with some 5000 cavalry and 30,000 footsoldiers | |
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| 334 BC |
| | Indulging in a moment of romantic tourism, Alexander visits Troy at the start of his Persian campaign | |
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| 334 BC |
| | At the river Granicus, not far from Troy, Alexander defeats a Persian army employing many Greek mercenaries | |
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| 333 BC |
| | At Issus, close to the Turkish border with Syria, Alexander defeats the Persian emperor Darius III, captures his family and treats them with courtesy | |
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| 333 BC |
| | At Gordium, in central Turkey, Alexander is credited with cutting the mythical Gordian Knot (identifying him as the ruler of Asia) | |
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| 332 BC |
| | Alexander moves south through Syria and Palestine, excluding the Persian fleet from their familiar harbours | |
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| 332 BC |
| | Tyre, the only coastal city to offer serious resistance to Alexander, is taken and destroyed after a siege of seven months | |
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